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KMID : 0811720040080000189
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Korean Journal of Physiology & Pharmacology
2004 Volume.8 No. 0 p.189 ~ p.0
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15 Dimensional SOM Analysis Based on the Response in Dorsal Horn; Activity of Dorsal Horn Neurons Evoked by Electrical Stimulation Changes Spatiotemporaly before and after Subcutaneous Injection of Capsaicin
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Lee Kwan-Yup
Lee Hyung-Cheol
Kim Chun
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Abstract
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Change of response pattern in deep dorsal horn neurons to the subcutaneous electrical stimulation on the receptive field was quantified by simultaneously recording from single-unit neural ensembles in anesthetized rats before and after injection of capsaicin (n = 29, total 300 neurons). The response of dorsal horn neurons can be divided into three parts, such as Ab, Ad, and C components based on the conduction velocity of their afferent fibers. We defined the responses within 15ms after stimulation on the peripheral receptive field as Ab, 16～70 ms as Ad, and 71～300 ms as C fiber component. And then, we classified neurons in accordance with their main response of fiber component (Ab, Ad, C, Ab+Ad, Ab+C, Ad+C, Ab+Ad +C). Capsaicin, a compound that excites and then inactivates a subset of peripheral C and Ad fibers, triggered increases in spontaneous firing of spinal dorsal horn neurons, as well as induces hyperalgesia in a large area surrounding the application site. We considered a self-organizing model of neural representation of the firing pattern of neurons based on neuronal discharge rates. Self organizing map (SOM) is used to select the optimal set of weight in the model to determine the contribution of an individual neurons to an overall firing representation. Neurons included in a same type classified by their main component of afferent fiber response distributed in the neighborhood on the SOM, respectively. Observing the firing rate of each groups on the SOM at three periods (-15 ms, 16～70 ms, 71～300 ms) after electrical stimulation, we found that the groups showing highest rate of response had changed over another types of neuron after subcutaneous injection of capsaicin. this research was supported by grants 2002-EP0026 from Korea research foundation.
Source: Korean Journal of Physiology & Pharmacology.2004 Oct;8(Suppl I):S139-S139
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KEYWORD
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SOM, Dorsal horn neuron, Capsaicin
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